業 績 PUBLICATIONS

2020年

1. Nguyen T, Hosono Y, Shimizu T, Yamasaki S, Williams SJ.
   Candida albicans Q1 steryl 6-O-acyl-a-D-mannosides agonize signalling through Mincle.
   Chem. Commun. (Camb). 56:15060-15063, 2020

2. Matsuoka T, Motozono C, Hattori A, Kakeya H, Yamasaki S, Oishi S, Ohno H, Inuki S.
   The effects of 5-OP-RU stereochemistry on its stability and MAIT-MR1 axis.
   Chembiochem. 18:7907-7915, 2020

3. Smith DGM, Ito E, Yamasaki S, Williams SJ.
   Cholesteryl 6-O-acyl-α-glucosides from diverse Helicobacter spp. signal through the C-type lectin receptor Mincle.
   Org. Biomol. Chem. 18:7907-7915, 2020

4. Nasu J, Uto T, Fukaya T, Takagi H, Fukui T, Miyanaga N, Nishikawa Y, Yamasaki S, Yamashita Y, Sato K.
   Pivotal role of the carbohydrate recognition domain in self-interaction of CLEC4A to elicit the ITIM-mediated inhibitory function in murine conventional dendritic cells in vitro.
   Int. Immunol. 32:673-682, 2020

5. Hollwedel FD, Maus R, Stolper J, Khan A, Stocker BL, Timmer MSM, Lu X, Pich A, Welte T, Yamasaki S, Maus UA.
   Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice.
   J. Immunol. 205:3390-3399,  2020

6. Sato Y, Sato K, Yamamoto H, Kasamatsu J, Miyasaka T, Tanno D, Miyahara A, Kagesawa T, Oniyama A, Kawamura K, Yokoyama R, Kitai Y, Umeki A, Ishizuka S, Takano K, Shiroma R, Nakahata N, Kawakami K, Kanno E, Tanno H, Yamasaki S, Hara H, Ishii K, Kawakami K.
   Limited Role of Mincle in the Host Defense Against Infection with Cryptococcus deneoformans.
   Infect. Immun. 88: e00400-00420, 2020

7. Jin S, Vu HT, Hioki K, Noda N, Yoshida H, Shimane T, Ishizuka , Takashima I, Mizuhata Y, Pe KB, Ogawa T, Nishimura N, Packwood D, Tokitoh N, Kurata H, Yamasaki S, Ishii KJ, Uesugi M.
   Discovery of Self-Assembling Small Molecules as Vaccine Adjubants.
   Angew. Chem. Int. Ed. Engl.  60:961-969, 2020

8. Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T.
   C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury.
   J. Exp. Med. 217: e20192230, 2020
9. Arai Y, Torigoe S, Matsumaru T, Yamasaki S, Fujimoto Y.
   The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac₁PIM₁: its synthesis and immunomodulatory function.
   Org. Biomol. Chem. 18: 3659-3663, 2020
10. Watanabe M, Omahdi Z, Yamasaki S.
    Direct Binding Analysis Between C-Type Lectins and Glycans Using Immunoglobulin Receptor Fusion Proteins.
    Methods Mol. Biol. 2132:119-28. 2020
11. Toyonaga K, Yamasaki S.
    Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor.
    Curr. Top. Microbiol. Immunol. 429:103-115, 2020 
12. Holzheimer M, Reijneveld JF, Ramnarine AK, Misiakos G, Young DC, Ishikawa E, Cheng TY, Yamasaki S, Moody DB, Van Rhijn I, Minnaard AJ.
    Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity.
    ACS Chem. Biol. 15:1835-1841, 2020
13. Braganza CD, Motozono C, Sonoda KH, Yamasaki S, Shibata K, Timmer MSM, Stocker BL.
    Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands.
    Chem. Commun. (Camb). 56:5291-4. 2020
14. Smith DGM, Hosono Y, Nagata M, Yamasaki S, Williams SJ.
    Design of potent Mincle signalling agonists based on an alkyl β-glucoside template.
    Chem. Commun. (Camb). 56:4292-5. 2020
15. Omahdi Z, Horikawa Y, Nagae M, Toyonaga K, Imamura A, Takato K, Teramoto T, Ishida H, Kakuta Y, Yamasaki S.
    Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.
    J. Biol. Chem. 295:5807-17. 2020
16. Zhang S, Liu H, Yin M, Pei X, Hausser A, Ishikawa E, Yamasaki S, Jin ZG.
    Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
    Hepatology  Feb 11, 2020 (Online ahead of print)