業 績 PUBLICATIONS

Major Recent Publications

  1. Ishikawa E, Kosako H, Motooka D, Imasaka M, Watarai H, Ohmuraya M, Yamasaki S.
    Invariant TCR-triggered Protein kinase D activation mediates NKT cell development.
    J. Exp. Med. 222:e20250541, 2025
  2. Hosono Y, Tomiyasu N, Kasai H, Ishikawa E, Takahashi M, Imamura A, Ishida H, Compostella F, Kida H, Kumanogoh A, Bamba T, Izumi Y, Yamasaki S.
    Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells.
    J. Exp. Med. 222:e20240728, 2025
  3. Sakai Y, Asa M, Hirose M, Kusuhara W, Fujiwara N, Tamashima H, Ikazaki T, Oka S, Kuraba K, Tanaka K, Yoshiyama T, Nagae M, Hoshino Y, Motooka D, Van Rhijn I, Lu X, Ishikawa E, Moody DB, Kato T, Inuki S, Hirai G, Yamasaki S.
    A conserved human CD4+ T cell subset recognizing the mycobacterial adjuvant trehalose monomycolate
    J. Clin. Invest. 135:e185443, 2024
  4. Reis E Sousa C, Yamasaki S, Brown GD.
    Myeloid C-type lectin receptors in innate immune recognition.
    Immunity 57:700-717, 2024
  5. Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S.
    Sulfated bile acid is a host-derived ligand for MAIT cells.
    Sci. Immunol. 9:eade6924, 2024
  6. Oka S, Watanabe M, Ito E, Takeyama A, Matsuoka T, Takahashi M, Izumi Y, Arichi N, Ohno H, Yamasaki S, Inuki S.
    Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle.
    J. Am. Chem. Soc. 145:18538-18548, 2023
  7. Ishizuka S, van Dijk JHM, Kawakita T, Miyamoto Y, Maeda Y, Goto M, Le Calvez G, Groot LM, Witte MD, Minnaard AJ, van der Marel GA, Ato M, Nagae M, Codée JDC, Yamasaki S.
    PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
    ACS Cent. Sci. 9:1388-1399, 2023
  8. Watanabe M, Motooka D, Yamasaki S.
    The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells.
    Sci. Signal. 16:eabn9909, 2023
  9. Schutt CR, Yamasaki S.
    Lectin recruits pathogenic bugs.
    J. Exp. Med. 220:e20221732, 2023
  10. Shimizu T, Schutt CR, Izumi Y, Tomiyasu N, Omahdi Z, Kano K, Takamatsu H, Aoki J, Bamba T, Kumanogoh A, Takao M, Yamasaki S.
    Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease.
    Immunity 56:307-319, 2023
  11. Haji S, Ito T, Guenther C, Nakano M, Shimizu T, Mori D, Chiba Y, Tanaka M, Mishra SK, Willment JA, Brown GD, Nagae M, Yamasaki S.
    Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2.
    eLife 11: e83037, 2022
  12. Shibata K, Motozono C, Nagae M, Shimizu T, Ishikawa E, Motooka D, Okuzaki D, Izumi Y, Takahashi M, Fujimori N, Wing JB, Hayano T, Asai Y, Bamba T, Ogawa Y, Furutani-Seiki M, Shirai M, Yamasaki S.
    Symbiotic bacteria-dependent expansion of M1-reactive T cells causes autoimmunity in the absence of Bcl11b.
    Nat. Commun. 13: 6948, 2022
  13. Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.
    Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
    J. Exp. Med. 218: e20211327, 2021
  14. Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B, Timmer MS, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S.
    Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
    J. Exp. Med. 218: e20200815, 2021 
  15. Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.
    Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.
    Proc. Natl. Acad. Sci. USA. 115:E10662-71. 2018
  16. Shiokawa M, *Yamasaki S, *Saijo S.
    C-type lectin receptors in anti-fungal immunity.
    Curr. Opin. Microbiol. 40: 123-30. 2017
  17. Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S.
    Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.
    Proc. Natl. Acad. Sci. USA. 114: E3285-94. 2017
  18. #Behler-Janbeck F, #Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, *Yamasaki S, *Maus UA.
    C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia.
    PLoS Pathog. 12: e1006038. 2016
  19. Ishikawa E, Mori D, Yamasaki S.
    Recognition of Mycobacterial Lipids by Immune Receptors.
    Trends Immunol. 38: 66-76. 2017
  20. Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Mastuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S.
    C-type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection.
    Immunity 45:1245-57. 2016
  21. Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.
    Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
    Nat. Commun. 7:12756. 2016
  22. Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, Yamasaki S.
    Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.
    Immunity 41:402-13. 2014
  23. Yamasaki S.
    Clec12a: Quieting the Dead.
    Immunity 40:309-11. 2014
  24. Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K.
    Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
    Proc. Natl. Acad. Sci. USA 110:17438-43. 2013
  25. Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S.
    C-Type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
    Immunity 38:1050-62. 2013
  26. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, Yamasaki S.
    Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia.
    Cell Host Microbe 13:477-88. 2013
  27. Oh-hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, Rao A, Takayanagi H.
    Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
    Immunity 38:881-95. 2013
  28. Ishikawa E, Miyake Y, Hara H, Saito T, Yamasaki S.
    Germ-line elimination of electric charge on pre-T-cell receptor(TCR) impairs autonomous signaling for β-selection and TCR repertoire formation.
    Proc. Natl. Acad. Sci. USA 107:19979-84. 2010
  29. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S.
    Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.
    J. Exp. Med. 206:2879-88. 2009
  30. Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
    C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.
    Proc. Natl. Acad. Sci. USA 106:1897-902. 2009
  31. Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T.
    Mincle is an ITAM-coupled activating receptor that senses damaged cells.
    Nat. Immunol. 9:1179-88. 2008
  32. Yamasaki S, Saito T.
    Molecular basis for pre-TCR-mediated autonomous signaling.
    Trends. Immunol. 28:39-43. 2007
  33. Yamasaki S, Ishikawa E, Sakuma M, Ogata K, Sakata-Sogawa K, Hiroshima M, Wiest DL, Tokunaga M, Saito T.
    Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.
    Nat. Immunol. 7:67-75. 2006
PAGETOP