業 績 PUBLICATIONS

Major Recent Publications

  1. Reis E Sousa C, Yamasaki S, Brown GD.
    Myeloid C-type lectin receptors in innate immune recognition.
    Immunity 57:700-717, 2024
  2. Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S.
    Sulfated bile acid is a host-derived ligand for MAIT cells.
    Sci. Immunol. 9:eade6924, 2024
  3. Oka S, Watanabe M, Ito E, Takeyama A, Matsuoka T, Takahashi M, Izumi Y, Arichi N, Ohno H, Yamasaki S, Inuki S.
    Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle.
    J. Am. Chem. Soc. 145:18538-18548, 2023
  4. Ishizuka S, van Dijk JHM, Kawakita T, Miyamoto Y, Maeda Y, Goto M, Le Calvez G, Groot LM, Witte MD, Minnaard AJ, van der Marel GA, Ato M, Nagae M, Codée JDC, Yamasaki S.
    PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
    ACS Cent. Sci. 9:1388-1399, 2023
  5. Watanabe M, Motooka D, Yamasaki S.
    The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells.
    Sci. Signal. 16:eabn9909, 2023
  6. Schutt CR, Yamasaki S.
    Lectin recruits pathogenic bugs.
    J. Exp. Med. 220:e20221732, 2023
  7. Shimizu T, Schutt CR, Izumi Y, Tomiyasu N, Omahdi Z, Kano K, Takamatsu H, Aoki J, Bamba T, Kumanogoh A, Takao M, Yamasaki S.
    Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease.
    Immunity 56:307-319, 2023
  8. Haji S, Ito T, Guenther C, Nakano M, Shimizu T, Mori D, Chiba Y, Tanaka M, Mishra SK, Willment JA, Brown GD, Nagae M, Yamasaki S.
    Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2.
    eLife 11: e83037, 2022
  9. Shibata K, Motozono C, Nagae M, Shimizu T, Ishikawa E, Motooka D, Okuzaki D, Izumi Y, Takahashi M, Fujimori N, Wing JB, Hayano T, Asai Y, Bamba T, Ogawa Y, Furutani-Seiki M, Shirai M, Yamasaki S.
    Symbiotic bacteria-dependent expansion of M1-reactive T cells causes autoimmunity in the absence of Bcl11b.
    Nat. Commun. 13: 6948, 2022
  10. Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.
    Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
    J. Exp. Med. 218: e20211327, 2021
  11. Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B, Timmer MS, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S.
    Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
    J. Exp. Med. 218: e20200815, 2021 
  12. Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.
    Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.
    Proc. Natl. Acad. Sci. USA. 115:E10662-71. 2018
  13. Shiokawa M, *Yamasaki S, *Saijo S.
    C-type lectin receptors in anti-fungal immunity.
    Curr. Opin. Microbiol. 40: 123-30. 2017
  14. Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S.
    Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.
    Proc. Natl. Acad. Sci. USA. 114: E3285-94. 2017
  15. #Behler-Janbeck F, #Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, *Yamasaki S, *Maus UA.
    C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia.
    PLoS Pathog. 12: e1006038. 2016
  16. Ishikawa E, Mori D, Yamasaki S.
    Recognition of Mycobacterial Lipids by Immune Receptors.
    Trends Immunol. 38: 66-76. 2017
  17. Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Mastuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S.
    C-type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection.
    Immunity 45:1245-57. 2016
  18. Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.
    Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
    Nat. Commun. 7:12756. 2016
  19. Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, Yamasaki S.
    Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.
    Immunity 41:402-13. 2014
  20. Yamasaki S.
    Clec12a: Quieting the Dead.
    Immunity 40:309-11. 2014
  21. Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K.
    Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
    Proc. Natl. Acad. Sci. USA 110:17438-43. 2013
  22. Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S.
    C-Type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
    Immunity 38:1050-62. 2013
  23. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, Yamasaki S.
    Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia.
    Cell Host Microbe 13:477-88. 2013
  24. Oh-hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, Rao A, Takayanagi H.
    Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
    Immunity 38:881-95. 2013
  25. Ishikawa E, Miyake Y, Hara H, Saito T, Yamasaki S.
    Germ-line elimination of electric charge on pre-T-cell receptor(TCR) impairs autonomous signaling for β-selection and TCR repertoire formation.
    Proc. Natl. Acad. Sci. USA 107:19979-84. 2010
  26. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S.
    Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.
    J. Exp. Med. 206:2879-88. 2009
  27. Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
    C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.
    Proc. Natl. Acad. Sci. USA 106:1897-902. 2009
  28. Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T.
    Mincle is an ITAM-coupled activating receptor that senses damaged cells.
    Nat. Immunol. 9:1179-88. 2008
  29. Yamasaki S, Saito T.
    Molecular basis for pre-TCR-mediated autonomous signaling.
    Trends. Immunol. 28:39-43. 2007
  30. Yamasaki S, Ishikawa E, Sakuma M, Ogata K, Sakata-Sogawa K, Hiroshima M, Wiest DL, Tokunaga M, Saito T.
    Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.
    Nat. Immunol. 7:67-75. 2006
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