業 績 PUBLICATIONS

Major Recent Publications

  1. Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B, Timmer MS, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S.
    Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
    J. Exp. Med. 218: e20200815, 2021 
  2. Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.
    Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.
    Proc. Natl. Acad. Sci. USA. 115:E10662-71. 2018
  3. Shiokawa M, *Yamasaki S, *Saijo S.
    C-type lectin receptors in anti-fungal immunity.
    Curr. Opin. Microbiol. 40: 123-30. 2017
  4. Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S.
    Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.
    Proc. Natl. Acad. Sci. USA. 114: E3285-94. 2017
  5. #Behler-Janbeck F, #Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, *Yamasaki S, *Maus UA.
    C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia.
    PLoS Pathog. 12: e1006038. 2016
  6. Ishikawa E, Mori D, Yamasaki S.
    Recognition of Mycobacterial Lipids by Immune Receptors.
    Trends Immunol. 38: 66-76. 2017
  7. Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Mastuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S.
    C-type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection.
    Immunity 45:1245-57. 2016
  8. Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.
    Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
    Nat. Commun. 7:12756. 2016
  9. Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-hora M, Akashi K, Yamasaki S.
    Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.
    Immunity 41:402-13. 2014
  10. Yamasaki S.
    Clec12a: Quieting the Dead.
    Immunity 40:309-11. 2014
  11. Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K.
    Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
    Proc. Natl. Acad. Sci. USA 110:17438-43. 2013
  12. Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S.
    C-Type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
    Immunity 38:1050-62. 2013
  13. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, Yamasaki S.
    Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia.
    Cell Host Microbe 13:477-88. 2013
  14. Oh-hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, Rao A, Takayanagi H.
    Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
    Immunity 38:881-95. 2013
  15. Ishikawa E, Miyake Y, Hara H, Saito T, Yamasaki S.
    Germ-line elimination of electric charge on pre-T-cell receptor(TCR) impairs autonomous signaling for β-selection and TCR repertoire formation.
    Proc. Natl. Acad. Sci. USA 107:19979-84. 2010
  16. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S.
    Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.
    J. Exp. Med. 206:2879-88. 2009
  17. Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
    C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.
    Proc. Natl. Acad. Sci. USA 106:1897-902. 2009
  18. Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T.
    Mincle is an ITAM-coupled activating receptor that senses damaged cells.
    Nat. Immunol. 9:1179-88. 2008
  19. Yamasaki S, Saito T.
    Molecular basis for pre-TCR-mediated autonomous signaling.
    Trends. Immunol. 28:39-43. 2007
  20. Yamasaki S, Ishikawa E, Sakuma M, Ogata K, Sakata-Sogawa K, Hiroshima M, Wiest DL, Tokunaga M, Saito T.
    Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.
    Nat. Immunol. 7:67-75. 2006
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