Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
J. Exp. Med. 218:e20211327, 2021
Torigoe S, Schutt CR, Yamasaki S.
Immune discrimination of environmental spectrum through C-type lectin receptors.
Int. Immunol. 33:847-851, 2021
Kitai Y, Sato K, Tanno D, Yuan X, Umeki A, KasamatsuJ, Kanno E, Tanno H, Hara H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K.
Role of Dectin-2 in the Phagocytosis of Cryptococcus neoformans by Dendritic Cells.
Infect. Immun. 89: e0033021, 2021
Iijima A, Kanemaru K, Wang Y, Nabekura T, Nakamura Y, Fujisawa Y, Mori D, Ohmuraya M, Yamasaki S, Tahara-Hanaoka S, Shibuya A.
Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
Biochem. Biophys Res. Commun. 561: 101-105, 2021
Trujillo-Viera J, EI-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, loffler MC, Wihelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspport M, Sumara G.
Protein Kinase D2 drives chylomicron-mediated lipid transport in the interstine and promotes obesity.
EMBO Mol. Med. 13: e13548, 2021
Iizasa E, Chuma Y, Uematsu T, Kubota M, Kawaguchi H, Umemura M, Toyonaga K, Kiyohara H, Yano I, Colonna M, Sugita M, Matsuzaki G, Yamasaki S, Yoshida H, Hara H.
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation.
Nat. Commun. 12:2299, 2021
Yamamoto H, Tomiyama C, Sato K, Kasamatsu J, Takano K, Umeki A, Nakahara N, Miyasaka T, Kanno E, Tanno H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K.
Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin.
Biomed. Res. 42: 53-66, 2021
Lynch AT, Motozono C, Foster AJ, Kodar K, Dangerfield EM, Yamasaki S, Wedlock DN, Timmer MSM, Stocker BL.
Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner.
Bioorg. Chem. 110: 104747, 2021
Shiga M, Miyazaki J, Tanuma K, Nagumo Y, Yoshino T, Kandori S, Neguro H,Kojima T, Tanaka R, Okiyama N, Fujisawa Y, Watanabe M, Yamasaki S, Kiyohara H, Watanabe M, Sato TA, Tahara H, Nishiyama H, Yano I.
The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells.
Cancer Immunol. Immunother, 70: 2529-2543, 2021
Timmer MSM, Teunissen TJ, Kodar K, Foster AJ, Yamasaki S, Stocker BL.
Cholesteryl glucosides signal through the carbohydrate recognition domain of the macrophage inducible C-type lectin (mincle).
Org. Biomol .Chem. 19:2198-2202, 2021
Lynch AT, Motozono C, Foster AJ, Kodar K, Dangerfield EM, Yamasaki S, Wedlock DN, Timmer MSM, Stocker BL.
Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner.
Bioorg. Chem. 110:104747, 2021
Reijneveld JF, Holzheimer M, Young DC, Lopez K, Suliman S, Jimenez J, Calderon R, Lecca L, Murray MB, Ishikawa E, Yamasaki S, Minnaard AJ, Moody DB, Van Rhijn I.
Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.
Sci. Rep. 11:2010, 2021
Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B, Timmer MS, Smith DGM, Williams SJ, Bamba T, Miyamoto T, Arita M, Appelmelk BJ, Yamasaki S.
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
J. Exp. Med. 218: e20200815, 2021